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O-Level Biology · Coordination & Response

Nervous System & Sense Organs

Neurone structure, the reflex arc, the brain, the eye and the ear — everything you need for O-Level Biology, with model answers and a free quiz.

🧠 Pure Biology🇸🇬 Singapore O-Level📝 5 practice questionsUpdated May 2026

Contents

  1. Nervous System Overview
  2. Neurone Structure
  3. Synapses
  4. The Reflex Arc
  5. The Brain
  6. The Eye
  7. The Ear
  8. Nervous vs Hormonal Coordination
  9. Practice Quiz

1 · Nervous System Overview

Nervous system

A network of specialised cells (neurones) that rapidly coordinates responses to stimuli by transmitting electrical impulses. In humans it consists of the central nervous system (CNS: brain and spinal cord) and the peripheral nervous system (PNS: sensory and motor neurones connecting the CNS to the rest of the body).

The pathway for a voluntary response: Stimulus → Receptor → Sensory neurone → CNS (brain) → Motor neurone → Effector → Response

The nervous system allows rapid, short-lived, and highly localised responses — in contrast to the hormonal system, which is slower but longer-lasting.

2 · Neurone Structure

TypeFunctionKey features
Sensory neuroneCarries impulses from receptor to CNSLong dendron, short axon, cell body in middle
Motor neuroneCarries impulses from CNS to effectorShort dendrites, long axon, cell body at one end
Relay (connector) neuroneConnects sensory and motor neurones in CNSMany short processes; found only in brain and spinal cord

Parts of a Neurone

✅ Exam Tip

Drawing questions on neurones are common. Always label: cell body, nucleus, dendrites, axon, myelin sheath. For a motor neurone, show the cell body at one end with the axon extending away from it.

3 · Synapses

Synapse

A junction between two neurones (or between a neurone and an effector). There is a tiny gap called the synaptic cleft. Impulses cross the synapse chemically, not electrically.

How a Synapse Works

  1. An electrical impulse arrives at the pre-synaptic membrane.
  2. Synaptic vesicles fuse with the pre-synaptic membrane and release neurotransmitters (e.g. acetylcholine) into the synaptic cleft.
  3. Neurotransmitters diffuse across the cleft and bind to receptors on the post-synaptic membrane.
  4. This generates a new electrical impulse in the post-synaptic neurone.
  5. Neurotransmitters are broken down by enzymes (e.g. acetylcholinesterase) or reabsorbed to prevent continuous stimulation.
✅ Exam Tip

Synapses ensure impulses travel in ONE direction only — because neurotransmitter vesicles are only on the pre-synaptic side, and receptors only on the post-synaptic side. This is a very common "explain why" exam question.

4 · The Reflex Arc

Reflex action

A rapid, involuntary (automatic) response to a stimulus that does not involve conscious thought. It is coordinated by the spinal cord (not the brain), allowing a faster response.

The reflex arc pathway: Receptor → Sensory neurone → Relay neurone (in spinal cord) → Motor neurone → Effector

The brain is informed of the reflex via sensory neurones going up the spinal cord, but this happens after the response has already occurred — which is why you pull your hand away from a hot object before you consciously feel pain.

📝 Model Answer: Describe the pathway of a withdrawal reflex when touching a hot object (4 marks)

1. Pain receptors in the skin (fingertip) detect the stimulus (heat/pain) and generate an impulse.

2. The impulse is carried along the sensory neurone to the spinal cord.

3. In the spinal cord, the relay neurone connects the sensory neurone to the motor neurone.

4. The impulse is carried along the motor neurone to the effector (muscle in the arm), which contracts, pulling the hand away.

⚠️ Common Mistake

Many students say the reflex arc goes through the brain. It goes through the spinal cord. The brain is only notified — it does not direct the response.

5 · The Brain

RegionFunctions
CerebrumConscious thought, memory, language, voluntary movement, sensory perception, personality
CerebellumBalance and coordination of movement; fine motor control
Medulla oblongataControls autonomic (involuntary) functions: breathing rate, heart rate, peristalsis
HypothalamusThermoregulation, water balance (osmoregulation), hunger, sleep, controls the pituitary gland
Pituitary gland"Master gland" — releases hormones that control other endocrine glands

6 · The Eye

Key Structures and Functions

StructureFunction
CorneaTransparent layer; refracts (bends) most of the incoming light
IrisControls the size of the pupil; regulates the amount of light entering the eye
PupilThe opening in the iris; dilates in dim light, constricts in bright light
LensFine-tunes focusing by changing shape (accommodation)
Ciliary musclesContract/relax to change lens shape for focusing
Suspensory ligamentsAttach lens to ciliary body; taut when ciliary muscles relax (viewing distant object)
RetinaContains photoreceptors (rods and cones); converts light into electrical impulses
Fovea (yellow spot)Highest concentration of cones; point of sharpest vision
Blind spotWhere the optic nerve exits; no photoreceptors, so no image formed here
Optic nerveCarries electrical impulses from retina to the brain

Accommodation (Focusing)

Near objectDistant object
Ciliary musclesContractRelax
Suspensory ligamentsSlack/looseTaut/tense
Lens shapeFat (more curved)Thin (less curved)
RefractionMore (shorter focal length)Less (longer focal length)
⚠️ Most Common Exam Mistake

Students say "the lens gets bigger/smaller". The lens changes shape (fatter or thinner), not size. Also, for a near object the ciliary muscles contract — which is the opposite of what many students expect.

7 · The Ear

The ear has two roles: hearing and balance.

Hearing Pathway

Sound waves → ear canal → tympanic membrane (eardrum) vibrates → three ossicles (malleus, incus, stapes) amplify and transmit vibrations → oval window → fluid in the cochlea vibrates → hair cells in cochlea convert vibrations to electrical impulses → auditory nerve → brain.

Balance

The semicircular canals (three canals at right angles to each other) detect rotational movement. The utricle and saccule detect linear acceleration and gravity (static balance).

8 · Nervous vs Hormonal Coordination

FeatureNervous systemHormonal system
SpeedVery fast (milliseconds)Slower (seconds to minutes)
Signal typeElectrical impulseChemical (hormone in blood)
DurationShort-livedLong-lasting
SpecificitySpecific (target organ via nerve)Widespread (all cells with receptors)
TransmissionAlong neuronesVia bloodstream

🧠 Quick Practice Quiz

8 questions · O-Level style · Instant feedback

Question 1 of 8
Why can impulses only travel in one direction across a synapse?
Neurotransmitter vesicles are only present in the pre-synaptic knob, and receptor proteins that bind the neurotransmitter are only on the post-synaptic membrane — ensuring one-way transmission.
Question 2 of 8
When focusing on a nearby object, which of the following correctly describes the state of the ciliary muscles and suspensory ligaments?
For a near object: ciliary muscles contract → suspensory ligaments go slack → lens becomes fat (more curved) → more refraction → shorter focal length.
Question 3 of 8
Which part of the brain controls breathing rate and heart rate?
The medulla oblongata controls autonomic (involuntary) functions including breathing rate, heart rate and peristalsis.
Question 4 of 8
In a reflex arc, in which order do impulses travel through the following structures?
The correct reflex arc pathway is: Receptor → Sensory neurone → Relay neurone (in spinal cord) → Motor neurone → Effector.
Question 5 of 8
The blind spot of the eye has no photoreceptors. What is located at the blind spot?
The blind spot is where the optic nerve exits the retina. Since the nerve fibres take up space here, there are no rod or cone cells, so no image can be formed at that point.
Question 6 of 8
What is the role of the myelin sheath around a neurone?
The myelin sheath is a fatty insulating layer formed by Schwann cells. It prevents electrical 'leaking' and allows impulses to jump between nodes of Ranvier (saltatory conduction), greatly increasing the speed of transmission.
Question 7 of 8
Which brain region controls balance and coordination of movement?
The cerebellum coordinates voluntary movement and balance. The cerebrum handles conscious thought; the medulla controls autonomic functions (breathing, heart rate); the hypothalamus regulates temperature and water balance.
Question 8 of 8
What is the function of the fovea (yellow spot) in the eye?
The fovea contains the densest concentration of cone cells (colour receptors) and is the point where vision is sharpest in bright light. The blind spot (where optic nerve exits) has no photoreceptors; rods are concentrated in the peripheral retina for dim-light vision.
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